Sickle Cell Disease (SCD) which comes in diverse ranges of forms of Hemoglobin disorders (such as sickle cell hemoglobin S-HbSS and hemoglobin C-HbSC, sickle cell anemia (SCA), beta and alpha thalassemias, SD, and SE, etc.). SCD is a common genetic disorder in most sub-Saharan African countries with affecting rate of up to three percent of parturitions (births) as witness in various parts of the continents and especially in Nigeria. It is one of the most uncared non-communicable genetic disorder diseases that are characterized by series of anemia and sickling of red blood cells (RBCs) among Nigerians in recent time. The most common form of SC disorder is produced from the homozygosis of beta-globin S gene mutation (HbSS disease). These red blood cells disorders are portrayed with series of chronic, hemolytic anemia, various injury, vaso-occlusive crisis, stroke, and organ dysfunction in some cases. Patients (which includes children and adults) with SCD are familiar with relate traits and indications, problems and complications of the disease which increases with age. There have been reports of patients’ addiction to different types of prophylaxis drugs of SCD such as Tramadol, Pentazocine (Fortwin), Diclofenac injections, etc.; which are prevalent in tertiary institutions. The adequacy of proper data and information management support for managing SCD can reduce the rate of high early-mortality which has been on the rise in children, young adults and adults in Nigeria. The addition of health information management (HIM) programs for the SCD among these pairs will create an affordable method to perform an evaluation of SCD mortality among Nigerians with sufficient health information management.